PMID: 17259654

Gemignani F, Landi S, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Gaborieau V, Gioia-Patricola L, Bellini I, Barale R, Canzian F, Hall J, Boffetta P, Hung RJ, Brennan P
Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes.
Carcinogenesis. 2007 Jun;28(6):1287-93. Epub 2007 Jan 27., [PubMed]
Sentences
No. Mutations Sentence Comment
154 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 17259654:154:251
status: NEW
view ABCG2 p.Gln141Lys details
ABCG2 p.Val12Met
X
ABCG2 p.Val12Met 17259654:154:332
status: NEW
view ABCG2 p.Val12Met details
 Associations between lung cancer risk and SNPs belonging to genes involved in the phase II of xenobiotic metabolism SNP name rs no. Homozygotes common allele Heterozygotes Homozygotes rarer allele Ptrend Ca Co Ca Co ORa 95% CI Ca Co ORa 95% CI ABCG2: Q141K rs2231142 225 242 44 47 0.99 (0.61-1.63) 1 1 2.77 (0.15-52.00) 0.87 ABCG2: V12M rs2231137 171 190 15 10 1.91 (0.77-4.75) 0 1 - - 0.45 ALDH2: 348T.C-MspI rs440 187 202 94 96 0.94 (0.64-1.37) 9 7 1.18 (0.41-3.42) 0.91 ALDH2: 355G.A rs886205 184 204 99 93 1.04 (0.71-1.52) 10 9 0.99 (0.37-2.68) 0.88 ALDH2: 483T.C-HaeIII rs441 187 209 89 94 0.91 (0.62-1.34) 9 7 1.20 (0.41-3.46) 0.85 ALDH2: 69G.A rs4646777 191 213 89 89 0.98 (0.67-1.44) 10 8 1.07 (0.39-2.95) 0.99 COMT: IVS2-98A.G rs6269 123 125 136 134 1.17 (0.80-1.70) 36 57 0.74 (0.43-1.25) 0.52 COMT: 186C.G-L136L rs4818 123 124 138 135 1.17 (0.80-1.70) 34 50 0.76 (0.44-1.31) 0.64 COMT: H62H rs4633 60 77 151 149 1.14 (0.73-1.77) 80 78 1.04 (0.63-1.71) 0.92 COMT: V158M-472G.A rs4680 83 81 144 146 1.07 (0.70-1.62) 59 75 0.98 (0.60-1.62) 0.97 GSTA2: S112T rs1051739 70 90 74 84 1.19 (0.74-1.92) 63 49 1.88 (1.11-3.17) 0.02 GSTA4: 668C.T rs405729 86 87 129 148 1.04 (0.69-1.57) 74 72 1.12 (0.70-1.81) 0.64 GSTA4: Q117Q rs1802061 251 227 24 40 0.56 (0.31-1.01) 5 1 3.94 (0.43-36.38) 0.36 GSTM1: A/B and null rs1065411 82 97 18 15 1.63 (0.73-3.67) 50 42 1.39 (0.80-2.42) 0.24 GSTM3: 3 bp del-Mnl I rs1799735 113 132 41 39 1.29 (0.74-2.26) 2 5 0.30 (0.04-2.13) 0.88 GSTM3: IVS8À30 rs1537234 76 83 120 112 1.19 (0.76-1.85) 48 63 0.88 (0.52-1.50) 0.74 GSTM3: V224I rs7483 149 132 120 142 0.75 (0.52-1.09) 26 40 0.57 (0.32-1.04) 0.04 GSTP1: 313A.G-I105V rs947894 127 133 118 130 0.98 (0.67-1.43) 27 22 1.29 (0.67-2.49) 0.63 GSTP1: 341C.T-A114V rs1799811 244 265 47 47 1.08 (0.67-1.76) 6 1 8.47 (0.87-82.09) 0.20 GSTT2: 153 bp 3# of STP rs2719 60 72 107 132 1.14 (0.71-1.82) 57 54 1.55 (0.89-2.68) 0.13 GSTT2: M139I rs1622002 275 296 19 16 1.05 (0.50-2.21) 0 0 - - 0.89 MDR1: 2677G.T-S892A rs2032582 97 112 134 117 1.16 (0.78-1.73) 53 67 0.97 (0.60-1.58) 0.97 MDR1: 3435T.C rs1045642 62 86 164 141 1.56 (1.02-2.40) 65 81 1.18 (0.72-1.94) 0.50 MDR1: G411G rs1128503 96 106 134 125 1.03 (0.69-1.54) 46 64 0.82 (0.49-1.35) 0.50 MnSOD2: 1183C.T-V16A rs1799725 80 84 118 117 1.15 (0.75-1.77) 57 63 1.00 (0.60-1.66) 0.94 NAT1: 1088T.A rs1057126 190 180 77 101 0.67 (0.45-0.99) 7 12 0.87 (0.31-2.45) 0.08 NAT1: 1095A.C rs15561 155 140 74 104 0.63 (0.42-0.95) 18 22 0.83 (0.40-1.70) 0.10 NAT1: À344C.T rs4986988 219 219 14 17 0.85 (0.38-1.90) 2 1 1.23 (0.09-16.00) 0.80 NAT1: À40A.T rs4986989 248 256 17 23 0.81 (0.40-1.65) 2 1 1.64 (0.13-21.32) 0.75 NAT1: 445G.A-V149I rs4987076 243 259 18 26 0.75 (0.37-1.49) 3 1 1.85 (0.16-22.03) 0.64 NAT1: 459G.A-T153T rs4986990 245 264 17 25 0.78 (0.39-1.56) 2 1 1.62 (0.12-21.42) 0.65 NAT1: 559C.T-R187Stop rs5030839 227 238 1 2 0.90 (0.08-10.51) 0 0 - - 0.93 NAT1: 560G.A-R187Q rs4986782 270 300 5 3 2.17 (0.46-10.26) 0 0 - - 0.33 NAT2: 282C.T-Y94 rs1041983 135 144 114 120 1.13 (0.77-1.65) 34 33 1.28 (0.72-2.26) 0.36 NAT2: 341T.C-I114T rs1801280 69 73 101 96 1.16 (0.72-1.86) 51 47 1.02 (0.58-1.81) 0.86 NAT2: 481C.T-L161L rs1799929 113 105 127 161 0.73 (0.49-1.06) 43 36 1.07 (0.61-1.89) 0.65 NAT2: 590G.A-R197Q rs1799930 141 156 106 106 1.30 (0.88-1.91) 18 24 0.91 (0.46-1.83) 0.56 NAT2: 803A.G-L268R rs1208 96 88 117 139 0.73 (0.48-1.11) 52 64 0.69 (0.42-1.16) 0.13 NAT2: 857G.A-G286E rs1799931 244 258 15 12 1.34 (0.58-3.13) 0 0 - - 0.49 NQO1-DIA4: P187S rs1800566 202 207 75 97 0.74 (0.50-1.10) 17 11 1.89 (0.81-4.38) 0.96 NQO1-DIA4: R139W rs4986998 274 295 23 21 1.16 (0.59-2.27) 0 0 - - 0.67 SULT1A1: M223V rs1801030 282 302 0 1 - - 0 0 - - - SULT1A1: R213H-HaeII rs4149396 91 95 100 96 0.95 (0.61-1.47) 2 11 0.23 (0.05-1.18) 0.30 SULT1A2: 357 bp 3# of STP C.T rs11401 210 212 64 67 1.11 (0.72-1.71) 11 12 1.20 (0.48-2.98) 0.56 UGT1A7: N129K-R131K N/A 113 117 125 139 0.97 (0.65-1.43) 38 42 1.05 (0.61-1.81) 0.94 UGT1A7: W208R rs1126802 118 111 130 143 0.77 (0.52-1.12) 45 59 0.66 (0.39-1.10) 0.08 Ca, cases; Co, controls. ORa odd-ratio adjusted for age, sex, country and tobacco smoking. In bold, statistically significant results (P , 0.05). Login to comment