PMID: 17224914

Marsh S, Somlo G, Li X, Frankel P, King CR, Shannon WD, McLeod HL, Synold TW
Pharmacogenetic analysis of paclitaxel transport and metabolism genes in breast cancer.
Pharmacogenomics J. 2007 Oct;7(5):362-5. Epub 2007 Jan 16., [PubMed]
Sentences
No. Mutations Sentence Comment
16 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 17224914:16:186
status: VERIFIED
view ABCG2 p.Gln141Lys details
 ABCB1 appears to be the main paclitaxel transporter23,24 and variants in ABCB1 have been demonstrated to alter P-glycoprotein expression.25,26 A non-synonymous variant in ABCG2 (421C4A; Q141K) has been associated with drug resistance in vitro and in vivo,27-29 and with survival in prostate cancer patients receiving docetaxel chemotherapy (P ¼ 0.05),30 consequently, despite the lack of evidence associating taxane transport with ABCG2 the 421C4A variant was included in this study. Login to comment