PMID: 16928820

Chearwae W, Shukla S, Limtrakul P, Ambudkar SV
Modulation of the function of the multidrug resistance-linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin.
Mol Cancer Ther. 2006 Aug;5(8):1995-2006., [PubMed]
Sentences
No. Mutations Sentence Comment
117 ABCG2 p.Arg482Thr
X
ABCG2 p.Arg482Thr 16928820:117:99
status: VERIFIED
view ABCG2 p.Arg482Thr details
 Results Curcuminoids Inhibit the Efflux of Mitoxantrone and Pheophorbide a from Both Wild-type and R482T Mutant ABCG2-Expressing Cells To investigate the effect of curcuminoids on the accumulation of ABCG2 substrates, mitoxantrone and pheophorbide a accumulation assays (31) were done in wild-type 482R-HEK293 cells and mutant 482T ABCG2-expressing MCF-7 AdVp3000 cells. Login to comment