ABCMdb

PMID: 16879828

Benton JL, Ding J, Tsai MY, Shea S, Rotter JI, Burke GL, Post W
Associations between two common polymorphisms in the ABCA1 gene and subclinical atherosclerosis: Multi-Ethnic Study of Atherosclerosis (MESA).
Atherosclerosis. 2007 Aug;193(2):352-60. Epub 2006 Aug 1., [PubMed]

Sentences

No. Mutations Sentence Comment

0 ABCA1 p.Arg219Lys Atherosclerosis 193 (2007) 352-360 Associations between two common polymorphisms in the ABCA1 gene and subclinical atherosclerosis: Multi-Ethnic Study of Atherosclerosis (MESA) Jeana L. Bentonb, Jingzhong Dingi, Michael Y. Tsaid, Steven Sheae,f, Jerome I. Rotterg, Gregory L. Burkeh, Wendy Posta,c,* a Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Blalock 910H, 600 N. Wolfe Street, Baltimore, MD 21287, United States b The Johns Hopkins University School of Medicine, Baltimore, MD, United States c Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States d Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, United States e Department of Medicine, Columbia University, New York, NY, United States f Department of Epidemiology, Columbia University, New York, NY, United States g Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States h Department of Public Health Sciences, Wake Forest University, Winston-Salem, NC, United States i Department of Internal Medicine/Geriatrics, Wake Forest University, Winston-Salem, NC, United States Received 15 February 2006; received in revised form 9 May 2006; accepted 9 June 2006 Available online 1 August 2006 Abstract Objective: ABCA1 controls the first step in reverse cholesterol transport. The potential associations between G1051A (R219K) and -565C/T genetic polymorphisms in the ABCA1 gene, high-density lipoprotein cholesterol (HDL-C) and subclinical cardiovascular disease in the general population remains unclear. Login to comment 24 ABCA1 p.Arg219Lys Two common SNPs are G1051A (R219K, rs2230806) and -565C/T (previously designated as -477, rs2422493). Login to comment 25 ABCA1 p.Arg219Lys Two common SNPs are G1051A (R219K, rs2230806) and -565C/T (previously designated as -477, rs2422493). Login to comment 88 ABCA1 p.Arg219Lys G1051A (R219K) Demographic characteristics, laboratory values and subclinical disease measures for subjects stratified by G1051A genotype are presented in Table 3. Login to comment 89 ABCA1 p.Arg219Lys G1051A (R219K) Demographic characteristics, laboratory values and subclinical disease measures for subjects stratified by G1051A genotype are presented in Table 3. Login to comment