ABCMdb

PMID: 16808938

Robey RW, Fetsch PA, Polgar O, Dean M, Bates SE
The livestock photosensitizer, phytoporphyrin (phylloerythrin), is a substrate of the ATP-binding cassette transporter ABCG2.
Res Vet Sci. 2006 Dec;81(3):345-9. Epub 2006 Jun 30., [PubMed]

Sentences

No. Mutations Sentence Comment

54 ABCG2 p.Gln141Lys ABCG2 p.Gln141Lys A non-synonymous single nucleotide polymorphism in the human ABCG2 gene resulting in a glutamine to lysine change at amino acid 141 (Q141K) of the protein has been shown to result in impaired transport of substrate drugs and decreased ATPase activity compared to wild-type protein (Mizuarai et al., 2004; Morisaki et al., 2005). Login to comment