ABCMdb

PMID: 16611739

Tam SP, Mok L, Chimini G, Vasa M, Deeley RG
ABCA1 mediates high-affinity uptake of 25-hydroxycholesterol by membrane vesicles and rapid efflux of oxysterol by intact cells.
Am J Physiol Cell Physiol. 2006 Sep;291(3):C490-502. Epub 2006 Apr 12., [PubMed]

Sentences

No. Mutations Sentence Comment

158 ABCA1 p.Lys939Met ABCA1 p.Lys939Met ABCA1 p.Lys939Met ABCA1 p.Lys939Met ABCA1 p.Lys1952Met ABCA1 p.Lys1952Met ABCA1 p.Lys1952Met ABCA1 p.Lys1952Met A: immunoblots of total membrane proteins (15 ␮g) from vesicles containing wild-type ABCA1 (KK) and mutant proteins containing Met substitutions of the highly conserved Walker A Lys of nucleotide binding domain (NBD1; K939M, MK), NBD2 (K1952M, KM), or both NBDs (K939M/K1952M, MM), as well as control vesicles of beta-glucuronidase (beta-gus). Login to comment