PMID: 16343744

de Jong FA, de Jonge MJ, Verweij J, Mathijssen RH
Role of pharmacogenetics in irinotecan therapy.
Cancer Lett. 2006 Mar 8;234(1):90-106. Epub 2005 Dec 15., 2006-03-08 [PubMed]
Sentences
No. Mutations Sentence Comment
202 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 16343744:202:66
status: VERIFIED
view ABCG2 p.Gln141Lys details
 This ABCG2 421COA transversion results in an amino acid change of glutamine to lysine at codon 141 [151-153], and leads to altered substrate specificity and function of the mutant protein [151,154]. Login to comment