PMID: 16309825

Nakagawa H, Saito H, Ikegami Y, Aida-Hyugaji S, Sawada S, Ishikawa T
Molecular modeling of new camptothecin analogues to circumvent ABCG2-mediated drug resistance in cancer.
Cancer Lett. 2006 Mar 8;234(1):81-9. Epub 2005 Nov 23., 2006-03-08 [PubMed]
Sentences
No. Mutations Sentence Comment
112 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 16309825:112:129
status: VERIFIED
view ABCG2 p.Gln141Lys details
 However, one of the two homozygous individuals showed increased accumulation of SN-38 and SN-38 glucuronide, indicating that the Q141K homodimer may have an impaired function. Login to comment