ABCMdb

PMID: 15970668

Burger H, van Tol H, Brok M, Wiemer EA, de Bruijn EA, Guetens G, de Boeck G, Sparreboom A, Verweij J, Nooter K
Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps.
Cancer Biol Ther. 2005 Jul;4(7):747-52. Epub 2005 Jul 9., [PubMed]

Sentences

No. Mutations Sentence Comment

25 ABCG2 p.Arg482Thr Cell lines used: Caco2 parental, a human colon carcinoma cell line (ATCC, HTB-37); MCF-7 parental, a human breast carcinoma cell line (ATCC, HTB-22); MCF-7/MR, a mitoxantrone resistant counterpart of MCF-7 overexpressing wild-type ABCG2;11 MCF-7/AdVp3000, an MCF-7 derivative overexpressing the R482T variant of BCRP; KB-3-1, a human epidermoid carcinoma cell line (ATCC CCL-17) and the colchicine-selected derivative KB-8-5 overexpressing ABCB1;12 COS-1, an African green monkey cell line (ATCC, CRL-1650), and HEP3B, a hepatocarcinoma cell line (ATCC HB-8064). Login to comment 26 ABCG2 p.Arg482Thr Cell lines used: Caco2 parental, a human colon carcinoma cell line (ATCC, HTB-37); MCF-7 parental, a human breast carcinoma cell line (ATCC, HTB-22); MCF-7/MR, a mitoxantrone resistant counterpart of MCF-7 overexpressing wild-type ABCG2;11 MCF-7/AdVp3000, an MCF-7 derivative overexpressing the R482T variant of BCRP; KB-3-1, a human epidermoid carcinoma cell line (ATCC CCL-17) and the colchicine-selected derivative KB-8-5 overexpressing ABCB1;12 COS-1, an African green monkey cell line (ATCC, CRL-1650), and HEP3B, a hepatocarcinoma cell line (ATCC HB-8064). Login to comment