PMID: 15846474

Hirouchi M, Suzuki H, Sugiyama Y
Treatment of hyperbilirubinemia in Eisai hyperbilirubinemic rat by transfecting human MRP2/ABCC2 gene.
Pharm Res. 2005 Apr;22(4):661-6. Epub 2005 Apr 7., [PubMed]
Sentences
No. Mutations Sentence Comment
21 ABCC2 p.Ser789Phe
X
ABCC2 p.Ser789Phe 15846474:21:78
status: NEW
view ABCC2 p.Ser789Phe details
ABCC2 p.Ala1450Thr
X
ABCC2 p.Ala1450Thr 15846474:21:88
status: NEW
view ABCC2 p.Ala1450Thr details
 Although the wild-type MRP2 was exclusively localized at the apical membrane, S789F and A1450T MRP2 were located not only at the apical membrane but also in the intracellular compartment, suggesting that the in vivo function of these two kinds of variants may be lower than wild type MRP2 (12). Login to comment