PMID: 15798900

Sadlish H, Skach WR
Biogenesis of CFTR and other polytopic membrane proteins: new roles for the ribosome-translocon complex.
J Membr Biol. 2004 Dec;202(3):115-26., [PubMed]
Sentences
No. Mutations Sentence Comment
166 ABCC7 p.Asp924Val
X
ABCC7 p.Asp924Val 15798900:166:61
status: NEW
view ABCC7 p.Asp924Val details
 Interestingly, removal of a single charged residue from TM8 (D924V) prevented Asn908 from being glycosylated and at the same time conferred TM7-independent stop transfer activity onto the TM8 hydrophobic segment (Carveth et al., 2002). Login to comment 183 ABCC7 p.Asp924Val
X
ABCC7 p.Asp924Val 15798900:183:15
status: NEW
view ABCC7 p.Asp924Val details
 Similarly, the D924V mutation converts TM8 to a strong, independent stop transfer sequence but dramatically decreases CFTR chloride conductance (D. Dawson and W. Skach, unpublished observations). Login to comment