ABCMdb

PMID: 15753373

Elkind NB, Szentpetery Z, Apati A, Ozvegy-Laczka C, Varady G, Ujhelly O, Szabo K, Homolya L, Varadi A, Buday L, Keri G, Nemet K, Sarkadi B
Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib).
Cancer Res. 2005 Mar 1;65(5):1770-7., 2005-03-01 [PubMed]

Sentences

No. Mutations Sentence Comment

46 ABCG2 p.Lys86Met For our studies, we have generated retrovirally transduced A431 cells, expressing various levels of the wild-type ABCG2, or a functionally inactive mutant (K86M) ABCG2 variant. Login to comment 71 ABCG2 p.Lys86Met Accumulation of Hoechst 33342 dye was done by using intact A431 cells without (control) or with the overexpression of wild-type ABCG2 or its inactive K86M mutant in a fluorescence spectrophotometer (Perkin-Elmer LS 50B, Perkin-Elmer/Applied Biosystems, Foster City, CA) at 350 nm (excitation)/460 nm (emission) as described (31). Login to comment 317 ABCG2 p.Gln141Lys Imai Y, Nakane M, Kage K, et al. C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Login to comment 320 ABCG2 p.Gln141Lys Imai Y, Nakane M, Kage K, et al. C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Login to comment