PMID: 15557325

Koldamova RP, Lefterov IM, Staufenbiel M, Wolfe D, Huang S, Glorioso JC, Walter M, Roth MG, Lazo JS
The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease.
J Biol Chem. 2005 Feb 11;280(6):4079-88. Epub 2004 Nov 22., [PubMed]
Sentences
No. Mutations Sentence Comment
14 ABCA1 p.Arg219Lys
X
ABCA1 p.Arg219Lys 15557325:14:35
status: NEW
view ABCA1 p.Arg219Lys details
 Wollmer et al. (15) found that the R219K variant of ABCA1, associated with increased HDL cholesterol levels and a decreased risk of atherosclerosis (16), delayed the age of onset of late onset Alzheimer`s disease. Login to comment