ABCMdb

PMID: 15355921

de Jong FA, Marsh S, Mathijssen RH, King C, Verweij J, Sparreboom A, McLeod HL
ABCG2 pharmacogenetics: ethnic differences in allele frequency and assessment of influence on irinotecan disposition.
Clin Cancer Res. 2004 Sep 1;10(17):5889-94., 2004-09-01 [PubMed]

Sentences

No. Mutations Sentence Comment

23 ABCG2 p.Gln141Lys In particular, a single nucleotide polymorphism in exon 5 of the ABCG2 gene has been described in which a 421CϾA transversion results in an amino acid change of glutamine to lysine at codon 141 (14-16). Login to comment 108 ABCG2 p.Gln141Lys However, the low frequency of ABCG2 421A (Ͻ 1%) in this population is in line with earlier observations in Africans north of the Fig. 1 Boxplot of dose-normalized AUC of irinotecan (A), SN-38 (B), and SN-38G (C) as a function of the ABCG2 421CϾA (Q141K) genotype. Login to comment