PMID: 15170677

Yoshikawa M, Ikegami Y, Hayasaka S, Ishii K, Ito A, Sano K, Suzuki T, Togawa T, Yoshida H, Soda H, Oka M, Kohno S, Sawada S, Ishikawa T, Tanabe S
Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells.
Int J Cancer. 2004 Jul 20;110(6):921-7., 2004-07-20 [PubMed]
Sentences
No. Mutations Sentence Comment
169 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 15170677:169:24
status: VERIFIED
view ABCG2 p.Gln141Lys details
 This type of variation (Gln141Lys) has hitherto been reported as a naturally occurring SNP of ABCG2. Login to comment 170 ABCG2 p.Gln141Lys
X
ABCG2 p.Gln141Lys 15170677:170:4
status: VERIFIED
view ABCG2 p.Gln141Lys details
 The Gln141Lys polymorphism has recently been identified in healthy Japanese volunteers as well.29 We investigated the effects of this SNP on the substrate specificity of ABCG2, using ABCG2-transfected cells with Gln at amino acid 141. Login to comment