PMID: 15057243

Gray MA
Bicarbonate secretion: it takes two to tango.
Nat Cell Biol. 2004 Apr;6(4):292-4., [PubMed]
Sentences
No. Mutations Sentence Comment
82 ABCC7 p.Gly551Ser
X
ABCC7 p.Gly551Ser 15057243:82:148
status: NEW
view ABCC7 p.Gly551Ser details
 However, chloride channel activity alone is not necessarily sufficient to activate chloride-bicarbonate exchange: some CFTR mutations (for example, G551S) display near normal chloride N NPlasma membrane ETKF DTRL NBD1 NBD2 PKA phosphorylation SLC26 CFTR STAS PDZ binding protein C C C R N NPlasma membrane ETKF DTRL NBD1 NBD2 SLC26 CFTR STAS PDZ binding protein C R P P Figure 1 Interactions between CFTR and SLC26 transporters. CFTR and SLC26 are envisaged to interact through binding of their respective R and STAS domains, a process that is enhanced by PKA (protein kinase A)-mediated phosphorylation of the CFTR R domain1 (not shown). Login to comment