PMID: 14581585

Cai Z, Scott-Ward TS, Sheppard DN
Voltage-dependent gating of the cystic fibrosis transmembrane conductance regulator Cl- channel.
J Gen Physiol. 2003 Nov;122(5):605-20., [PubMed]
Sentences
No. Mutations Sentence Comment
385 ABCC7 p.Lys1250Ala
X
ABCC7 p.Lys1250Ala 14581585:385:155
status: NEW
view ABCC7 p.Lys1250Ala details
 Third, to investigate the flickery closures that interrupt bursts of channel openings, Zhou et al. (2001) analyzed the gating kinetics of the CFTR variant K1250A whose prolonged openings facilitate the discrimination of fast and slow gating events. Login to comment 397 ABCC7 p.Arg334Cys
X
ABCC7 p.Arg334Cys 14581585:397:148
status: NEW
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 Third, comparison of the data of Smith et al. (2001) and Gong and Linsdell (2003) suggests that the strong inward rectification of the CFTR variant R334C is not accounted for by voltage-dependent changes in i. Based on these data, we argue that voltage-dependent changes in CFTR channel gating contribute to the inward rectification of macroscopic CFTR Cl- currents. Login to comment