ABCMdb

PMID: 12069597

Cai J, Daoud R, Alqawi O, Georges E, Pelletier J, Gros P
Nucleotide binding and nucleotide hydrolysis properties of the ABC transporter MRP6 (ABCC6).
Biochemistry. 2002 Jun 25;41(25):8058-67., 2002-06-25 [PubMed]

Sentences

No. Mutations Sentence Comment

55 ABCC6 p.Arg1268Gln ABCC6 p.Arg1138Gln ABCC6 p.Arg1114Pro ABCC6 p.Arg1314Trp ABCC6 p.Trp1259Gly Interestingly, most of the single amino acid substitutions mapped in NBD2 of MRP6 (R1114P, R1138Q/ W, R1314W, W1259G, R1268Q) with none in NBD1. Login to comment 78 ABCC2 p.Gly389Cys Sequence analysis of this clone identified a double nucleotide change (G389C and C390G) from that of the published sequence, which results in a Ser to Thr substitution (at amino acid residue 122) within the first membrane-associated domain of the protein. Login to comment