ABCMdb

PMID: 11381133

Karttunen JT, Lehner PJ, Gupta SS, Hewitt EW, Cresswell P
Distinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP).
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7431-6. Epub 2001 May 29., [PubMed]

Sentences

No. Mutations Sentence Comment

122 ABCB3 p.Lys509Ala To explore the role of ATP hydrolysis in peptide translocation, we generated mutant polypeptides in which the ''Walker lysine`` was mutated to an alanine (K544A TAP1 and K509A TAP2). Login to comment 123 ABCB3 p.Lys509Ala To explore the role of ATP hydrolysis in peptide translocation, we generated mutant polypeptides in which the ''Walker lysine`` was mutated to an alanine (K544A TAP1 and K509A TAP2). Login to comment 283 ABCC7 p.Ser549Arg Not only is the absence of this serine unique among ABC transporters, but a mutation at this site in CFTR (S549R) is responsible for some cases of cystic fibrosis (46). Login to comment