PMID: 10990455

Wada Y, Yamashita T, Imai K, Miura R, Takao K, Nishi M, Takeshima H, Asano T, Morishita R, Nishizawa K, Kokubun S, Nukada T
A region of the sulfonylurea receptor critical for a modulation of ATP-sensitive K(+) channels by G-protein betagamma-subunits.
EMBO J. 2000 Sep 15;19(18):4915-25., [PubMed]
Sentences
No. Mutations Sentence Comment
124 ABCC8 p.Arg657Ala
X
ABCC8 p.Arg657Ala 10990455:124:310
status: NEW
view ABCC8 p.Arg657Ala details
 Aiming at identifying the critical amino acid residues on the SUR subunit interacting with Gbg2, conserved basic amino acid residues within these amino acid sequences, Arg656 and Arg657 in SL3, and His1501 and Arg1502 in ST3, were substituted by Ala to generate four mutant SUR2As: SLM1 (Arg656,657Ala), SLM2 (Arg657Ala), SLM3 (Arg656Ala) and STM1 (His1501Ala and Arg1502Ala). Login to comment