PMID: 10919864

Chan KW, Csanady L, Seto-Young D, Nairn AC, Gadsby DC
Severed molecules functionally define the boundaries of the cystic fibrosis transmembrane conductance regulator's NH(2)-terminal nucleotide binding domain.
J Gen Physiol. 2000 Aug;116(2):163-80., [PubMed]
Sentences
No. Mutations Sentence Comment
319 ABCC7 p.Lys1250Ala
X
ABCC7 p.Lys1250Ala 10919864:319:17
status: NEW
view ABCC7 p.Lys1250Ala details
 Moreover, mutant K1250A CFTR channels, in which ATP hydrolysis at NBD2 is severely impaired (Ramjeesingh et al., 1999), show brief WT-like openings at low micromolar [ATP], but extremely long openings at higher [ATP] that reflect binding at NBD2 of ATP that cannot be hydrolyzed (Zeltwanger et al., 1999); those results imply that the brief openings at low [ATP] involve only NBD1. Login to comment