ABCMdb

PMID: 10792060

Ostedgaard LS, Baldursson O, Vermeer DW, Welsh MJ, Robertson AD
A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution.
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5657-62., 2000-05-09 [PubMed]

Sentences

No. Mutations Sentence Comment

26 ABCC7 p.Ser660Ala ABCC7 p.Ser660Ala An example is CFTR-⌬R͞ S660A, in which residues 708-835 are deleted and Ser-660 is mutated to alanine (12, 19, 23). Login to comment 46 ABCC7 p.Ser660Ala 10 ͉ 5657-5662 S660A in lipid bilayers (13, 14). Login to comment 198 ABCC7 p.Glu826Lys ABCC7 p.Glu822Lys ABCC7 p.Arg792Gly ABCC7 p.Ala800Gly From this region, the mutations R792G, A800G, E822K, and E826K increase or decrease current, but have not been reported to alter channel properties (38, 39). Login to comment