ABCMdb

PMID: 10618714

Zhu K, Wang J, Zhu J, Jiang J, Shou J, Chen X
p53 induces TAP1 and enhances the transport of MHC class I peptides.
Oncogene. 1999 Dec 16;18(54):7740-7., [PubMed]

Sentences

No. Mutations Sentence Comment

89 ABCB3 p.Arg175His ABCB3 p.Arg273His In contrast, the luciferase activity for TAP1-Fluc was not increased by the mutants p53(V143A), p53(R175H), p53(R249S), or p53(R273H) (Figure 5c), consistent with the observation that mutant p53(R249S) was incapable of inducing TAP1 (Figure 1a). Login to comment 95 ABCB3 p.Arg175His ABCB3 p.Arg273His 5 mg of TAP1-Fluc was co-transfected into H1299 cells with 5 mg of pcDNA3 or a vector that expresses p53(V143A), p53(R175H), p53(R249S), or p53(R273H). Login to comment 190 ABCB3 p.Arg175His ABCB3 p.Arg273His TAP1-Fluc or GADD45-Fluc was co-transfected into H1299 cells with control vector pcDNA3 or a vector that expresses wild-type p53, p53(V143A), p53(R175H), p53(R249S), p53(R273H), p73a or p73b. Login to comment