ABCG2 p.Gln126Lys
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PMID: 26119820
[PubMed]
Ogura J et al: "Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen."
No.
Sentence
Comment
254
BCRP mutations, such as partially functional mutation Q126K and nonfunctional mutation Q126X, markedly increase gout risk [12,13], indicating that BCRP dysfunction affects serum uric acid level.
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ABCG2 p.Gln126Lys 26119820:254:54
status: NEW