PMID: 26119820

Ogura J, Kuwayama K, Sasaki S, Kaneko C, Koizumi T, Yabe K, Tsujimoto T, Takeno R, Takaya A, Kobayashi M, Yamaguchi H, Iseki K
Reactive oxygen species derived from xanthine oxidase interrupt dimerization of breast cancer resistance protein, resulting in suppression of uric acid excretion to the intestinal lumen.
Biochem Pharmacol. 2015 Sep 1;97(1):89-98. doi: 10.1016/j.bcp.2015.06.021. Epub 2015 Jun 25., [PubMed]
Sentences
No. Mutations Sentence Comment
254 ABCG2 p.Gln126*
X
ABCG2 p.Gln126* 26119820:254:87
status: NEW
view ABCG2 p.Gln126* details
ABCG2 p.Gln126Lys
X
ABCG2 p.Gln126Lys 26119820:254:54
status: NEW
view ABCG2 p.Gln126Lys details
 BCRP mutations, such as partially functional mutation Q126K and nonfunctional mutation Q126X, markedly increase gout risk [12,13], indicating that BCRP dysfunction affects serum uric acid level. Login to comment