ABCG2 p.Tyr459Cys
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PMID: 23467750
[PubMed]
Zoernig I et al: "Sequence mutations of the substrate binding pocket of stem cell factor and multidrug resistance protein ABCG2 in renal cell cancer: a possible link to treatment resistance."
No.
Sentence
Comment
92
Our data shows a mutation resulting in Y459C in the intracellular domain 1a (ICD1a).
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ABCG2 p.Tyr459Cys 23467750:92:39
status: NEW
PMID: 25445676
[PubMed]
Gal Z et al: "Mutations of the central tyrosines of putative cholesterol recognition amino acid consensus (CRAC) sequences modify folding, activity, and sterol-sensing of the human ABCG2 multidrug transporter."
No.
Sentence
Comment
224
Recently, the Y459C heterozygous mutation was reported to occur in patients with renal cancer [38].
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ABCG2 p.Tyr459Cys 25445676:224:14
status: NEW