ABCG1 p.Ser389Asp
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PMID: 22872754
[PubMed]
Gelissen IC et al: "Protein kinase A modulates the activity of a major human isoform of ABCG1."
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145
Figure 5A shows that basal cholesterol export from ABCG1(+12)-S389D- expressing cells was reduced compared with that of the wild-type ABCG1(+12), whereas incubation with H89 did not affect the cholesterol export capacity to HDL.
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ABCG1 p.Ser389Asp 22872754:145:62
status: NEW178 Fig. 5. Effect of H89 on ABCG1(+12)-S389D cholesterol export and protein levels.
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status: NEW179 A: Cholesterol export was measured as described inthelegendtoFig.2andMaterialsandMethodsfromABCG1(+12)- S389D-overexpressing cells and compared with the parental ABCG1(+12) cell line, with and without the addition of H89 (10 òe;M).
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status: NEW180 B: ABCG1(+12)-S389D-overexpressing cells were incubated with or without H89 in the presence of cycloheximide (10 òe;g/ml), as described in the legend to Fig. 4.
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ABCG1 p.Ser389Asp 22872754:180:14
status: NEW