ABCG1 p.Ser389Ala
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PMID: 22872754
[PubMed]
Gelissen IC et al: "Protein kinase A modulates the activity of a major human isoform of ABCG1."
No.
Sentence
Comment
137
Comparison of ABCG1 mRNA expression among the lines showed that expression was similar among the lines, with the exception of the S389A mutant ,which had approximately half the mRNA expression compared with the other cell lines (see supplementary Fig. IIIA).
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ABCG1 p.Ser389Ala 22872754:137:130
status: NEW141 However, HDL-mediated cholesterol efflux from the S389A mutant was on average slightly higher than the parental line, despite having lower mRNA expression, whereas cholesterol export from this mutant was completely unaffected by H89 treatment (Fig. 4).
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ABCG1 p.Ser389Ala 22872754:141:50
status: NEW177 H89 significantly increased cholesterol export from cells expressing ABCG1(+12), S388A, and S390A (P < 0.05), but not ABCG1(afa;12) or S389A.
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ABCG1 p.Ser389Ala 22872754:177:138
status: NEW