ABCB11 p.Tyr1311Ala
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PMID: 24378332
[PubMed]
Aida K et al: "Differential roles of ubiquitination in the degradation mechanism of cell surface-resident bile salt export pump and multidrug resistance-associated protein 2."
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4
The effect of UbDGG on BSEP internalization in these experiments was abrogated by treatment with chlorpromazine, an inhibitor of clathrin-mediated endocytosis, and the introduction of a Y1311A mutation into BSEP.
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ABCB11 p.Tyr1311Ala 24378332:4:186
status: NEW28 The cDNAs for human 3 FLAG-BSEP; 3 FLAG-BSEPY1311A , which incorporates a Y1311A mutation into 3 FLAG-BSEP; and MRP2 were cloned into pShuttle (Clontech, Mountain View, CA) (pShuttle-3 FLAG-BSEP and pShuttle-3 FLAG-BSEPY1311A ) and pcDNA3.1(1)-Neo (Invitrogen) (pcDNA3.1(1)-MRP2), respectively, as described previously (Hayashi et al., 2012a,b).
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ABCB11 p.Tyr1311Ala 24378332:28:76
status: NEW97 Elimination of the Inhibitory Effect of HA-UbDGG on the Internalization of 33 FLAG-BSEP by Treatment with Chlorpromazine and Introduction of a Y1311A Mutation.
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ABCB11 p.Tyr1311Ala 24378332:97:143
status: NEW