ABCB1 p.Glu506Gln
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PMID: 26517918
[PubMed]
Stockner T et al: "Investigating the dynamic nature of the ABC transporters: ABCB1 and MsbA as examples for the potential synergies of MD theory and EPR applications."
No.
Sentence
Comment
165
Mutation of the H-loop histidine H537A and especially the catalytic E506Q strongly reduced ATP hydrolysis rates and strongly reduced transporter function, while the binding affinity of ATP and analogs remained almost unchanged [68].
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ABCB1 p.Glu506Gln 26517918:165:68
status: NEW