PMID: 26517918

Stockner T, Mullen A, MacMillan F
Investigating the dynamic nature of the ABC transporters: ABCB1 and MsbA as examples for the potential synergies of MD theory and EPR applications.
Biochem Soc Trans. 2015 Oct 1;43(5):1023-32. doi: 10.1042/BST20150138., [PubMed]
Sentences
No. Mutations Sentence Comment
165 ABCB1 p.Glu506Gln
X
ABCB1 p.Glu506Gln 26517918:165:68
status: NEW
view ABCB1 p.Glu506Gln details
 Mutation of the H-loop histidine H537A and especially the catalytic E506Q strongly reduced ATP hydrolysis rates and strongly reduced transporter function, while the binding affinity of ATP and analogs remained almost unchanged [68]. Login to comment