ABCB1 p.Ser222Thr
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PMID: 11408605
[PubMed]
Gruol DJ et al: "The use of a novel taxane-based P-glycoprotein inhibitor to identify mutations that alter the interaction of the protein with paclitaxel."
No.
Sentence
Comment
219
Of the five mutations reported by Vo and Gruol to affect steroid-Pgp interactions, only one (S222T) causes a TABLE 3 Percentage loss in paclitaxel resistance for the variant cell lines listed in Table 2 A portion of the data that was used to generate Table 2 was converted from fractional loss to percentage loss of paclitaxel resistance.
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ABCB1 p.Ser222Thr 11408605:219:93
status: NEW225 Loss of paclitaxel resistance in this case, however, may be part of a pleiotropic phenomenon, because resistance to all six of the drugs tested were decreased in cells expressing the S222T mutation.
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ABCB1 p.Ser222Thr 11408605:225:183
status: NEW