ABCMdb

PMID: 11408605

Gruol DJ, Bernd J, Phippard AE, Ojima I, Bernacki RJ
The use of a novel taxane-based P-glycoprotein inhibitor to identify mutations that alter the interaction of the protein with paclitaxel.
Mol Pharmacol. 2001 Jul;60(1):104-13., [PubMed]

Sentences

No. Mutations Sentence Comment

219 ABCB1 p.Ser222Thr Of the five mutations reported by Vo and Gruol to affect steroid-Pgp interactions, only one (S222T) causes a TABLE 3 Percentage loss in paclitaxel resistance for the variant cell lines listed in Table 2 A portion of the data that was used to generate Table 2 was converted from fractional loss to percentage loss of paclitaxel resistance. Login to comment 225 ABCB1 p.Ser222Thr Loss of paclitaxel resistance in this case, however, may be part of a pleiotropic phenomenon, because resistance to all six of the drugs tested were decreased in cells expressing the S222T mutation. Login to comment