ABCC7 p.Thr788Ala
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PMID: 7684377
[PubMed]
Chang XB et al: "Protein kinase A (PKA) still activates CFTR chloride channel after mutagenesis of all 10 PKA consensus phosphorylation sites."
No.
Sentence
Comment
37
The following mutations were introduced into CFTR, S422A (TCT to GCT), S660A (TCA to GCA), S686A (TCT to GCT), S700A (TCT toGCT), S712A (TCC to GCC), S737A (TCC to GCC), S768A (TCT toGCT), T788A (ACAto GCA),S795A (TCA to GCA), S813A (TCA to GCA), S660E (TCA to GAA),S737E (TCC to GAG), S795E (TCA to GAA), and S813E (TCA to GAA).
X
ABCC7 p.Thr788Ala 7684377:37:189
status: NEW45 The DraIII/DraIIIfragment in pNUT-CFTR was replaced by the counterpart from pUCF2.5/6SA to generate 6SA.S686A,S768A, and T788Awere introduced into pUCF2.5/6SA by replacing the counterpart of DraIII/HpaI fragment (containing S660/686/700/712/737/768A) andStyIIStyI fragment (containing T788A/S795/813A).
X
ABCC7 p.Thr788Ala 7684377:45:285
status: NEW
PMID: 23760269
[PubMed]
Billet A et al: "Role of tyrosine phosphorylation in the muscarinic activation of the cystic fibrosis transmembrane conductance regulator (CFTR)."
No.
Sentence
Comment
102
Carbachol Stimulates CFTR through PKA and Non-PKA Signaling Pathways-To explore PKA-independent regulation of CFTR without using inhibitors that might have confounding effects on other pathways, we studied the activation of 15SA-CFTR (S422A/S660A/S670A/S686A/T690A/S700A/S712A/ S737A/S753A/S768A/T787A/T788A/S790A/S795A/S813A).
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ABCC7 p.Thr788Ala 23760269:102:302
status: NEW