ABCC8 p.Ser408Glu
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PMID: 12397023
[PubMed]
Gaden F et al: "Mechanism of restriction of normal and cystic fibrosis transmembrane conductance regulator-deficient human tracheal gland cells to adenovirus infection and ad-mediated gene transfer."
No.
Sentence
Comment
268
A less pronounced cytotoxic effect was observed in a Ser-to-Glu substitution at position 408 (Table 1).
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ABCC8 p.Ser408Glu 12397023:268:53
status: NEW272 (A) Control, Ad5LacZ-FiWT carried WT fibers, whereas Ad5LacZ-FiK7 and Ad5LacZ-Fi408K7 carried a stretch of seven lysine residues (K7) in fusion to the C-terminus of the knob domain, and Ad5LacZ-Fi408K7 contained an additional fiber knob mutation (S408E).
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ABCC8 p.Ser408Glu 12397023:272:247
status: NEW