ABCMdb

ABCC2 p.Cys363Ala

None has been submitted yet.

Publications

PMID: 15886292 [PubMed] Beringer PM et al: "Transporters and their impact on drug disposition."

No. Sentence Comment

50 and consists of 14 exons.25,26 As with MDR1, polymorphisms with SLCO1B1 are common, with at least 23 single nucleotide polymorphisms and 17 haplotypes identified.27,33 Single nucleotide polymorphisms that occur at a high frequency are e4/A388G, C363A, e5/T521C, A2000G, and G1463C. Five haplotypes are common (OATP-C*1a, OATP-C*1b, OATP-C*5, OATP-C*9, OATP-C*15), with altered protein function occurring with all except OATP-C*1a. Login to comment
172 The frequency of the e26/3435C allele and the mh7 haplotype occurs more frequently in African and African Americans than other populations.62,65 As with MDR1, polymorphisms with SLCO1B1 are common, with at least 23 single nucleotide polymorphisms and 17 haplotypes identified.26,66 Single nucleotide polymorphisms that occur at a high frequency are e4/A388G, C363A, e5/T521C, A2000G, and G1463C. Five haplotypes are common (OATP-C*1a, OATP-C*1b, OATP-C*5, OATP-C*9, OATP-C*15), with altered protein function occurring with all haplotypes except OATP-C*1a. Login to comment