PMID: 15886292

Beringer PM, Slaughter RL
Transporters and their impact on drug disposition.
Ann Pharmacother. 2005 Jun;39(6):1097-108. Epub 2005 May 10., [PubMed]
Sentences
No. Mutations Sentence Comment
50 ABCC2 p.Cys363Ala
X
ABCC2 p.Cys363Ala 15886292:50:245
status: NEW
view ABCC2 p.Cys363Ala details
 and consists of 14 exons.25,26 As with MDR1, polymorphisms with SLCO1B1 are common, with at least 23 single nucleotide polymorphisms and 17 haplotypes identified.27,33 Single nucleotide polymorphisms that occur at a high frequency are e4/A388G, C363A, e5/T521C, A2000G, and G1463C. Five haplotypes are common (OATP-C*1a, OATP-C*1b, OATP-C*5, OATP-C*9, OATP-C*15), with altered protein function occurring with all except OATP-C*1a. Login to comment 172 ABCC2 p.Cys363Ala
X
ABCC2 p.Cys363Ala 15886292:172:359
status: NEW
view ABCC2 p.Cys363Ala details
 The frequency of the e26/3435C allele and the mh7 haplotype occurs more frequently in African and African Americans than other populations.62,65 As with MDR1, polymorphisms with SLCO1B1 are common, with at least 23 single nucleotide polymorphisms and 17 haplotypes identified.26,66 Single nucleotide polymorphisms that occur at a high frequency are e4/A388G, C363A, e5/T521C, A2000G, and G1463C. Five haplotypes are common (OATP-C*1a, OATP-C*1b, OATP-C*5, OATP-C*9, OATP-C*15), with altered protein function occurring with all haplotypes except OATP-C*1a. Login to comment