ABCC8 p.Glu1305Ala
[switch to full view]Comments [show]
None has been submitted yet.
PMID: 18450778
[PubMed]
Dupuis JP et al: "Three C-terminal residues from the sulphonylurea receptor contribute to the functional coupling between the K(ATP) channel subunits SUR2A and Kir6.2."
No.
Sentence
Comment
53
The exact amino acid composition of SUR2A-MRP1 chimeric constructs and mutants were: S1M, SUR2A(M1-V1275) + MRP1(E1262-R1342) + SUR2A(M1358-K1545); S2M, SUR2A(M1-V1275) + MRP1(E1262-L1300) + SUR2A(R1316-K1545); S3M, SUR2A(M1-V1315) + MRP1(R1301-R1342) + SUR2A(M1358-K1545); S4M, SUR2A(M1-V1275) + MRP1(E1262-E1271) + SUR2A(S1286-K1545); S5M, SUR2A(M1-E1285) + MRP1(K1272-P1283) + SUR2A(P1299-K1545); S6M, SUR2A(M1-V1298) + MRP1(P1284-G1291) + SUR2A(E1307-K1545); S7M, SUR2A(M1-Q1304) + MRP1(V1290-L1300) + SUR2A(R1316-K1545); SUR2A(EIL/VFY), SUR2A with mutations E1305V, I1310F and L1313Y; S7M(VFY/EIL), S7M with mutations V1305E, F1310I and Y1313L; SUR2A(EIL/AAA), SUR2A with mutations E1305A, I1310A and L1313A.
X
ABCC8 p.Glu1305Ala 18450778:53:687
status: NEW
PMID: 26416970
[PubMed]
Principalli MA et al: "Kir6.2 activation by sulfonylurea receptors: a different mechanism of action for SUR1 and SUR2A subunits via the same residues."
No.
Sentence
Comment
64
V1290Q, F1295I, and Y1298L, SUR1(QIL/III) = Q1342I, I1347I, and L1350I, SUR1(QIL/AAA) = Q1342A, I1347A, and L1350A, SUR1(QIL/GGG) = Q1342G, I1347G, and L1350G, SUR2A(EIL/III) = E1305I, I1310I, and L1313I, SUR2A(EIL/AAA) = E1305A, I1310A, and L1313A, SUR2A(EIL/GGG) = E1305G, I1310G, and L1313G.
X
ABCC8 p.Glu1305Ala 26416970:64:222
status: NEW