ABCMdb

PMID: 26416970

Principalli MA, Dupuis JP, Moreau CJ, Vivaudou M, Revilloud J
Kir6.2 activation by sulfonylurea receptors: a different mechanism of action for SUR1 and SUR2A subunits via the same residues.
Physiol Rep. 2015 Sep;3(9). pii: e12533. doi: 10.14814/phy2.12533., [PubMed]

Sentences

No. Mutations Sentence Comment

57 ABCC1 p.Phe1295Ile ABCC8 p.Val1290Gln ABCC1 p.Tyr1298Leu The amino acid composition of the constructs were as follows: SUR1S1M = SUR1(M1-V1313) + MRP1(V1261-F1341) + SUR1(R1394-K1582); SUR1S2M = SUR1 (M1-P1336) + MRP1(P1284-L1300) + SUR1(V1352-K1582); SUR1S3M = SUR1 with mutations N1338S, I1345V, S1351C, and V1352L; SUR1S4M = SUR1 with mutations K1337S, D1341Q, K1344R, Q1346E, and Q1348R; SUR1(QIL/VFY) = SUR1 with mutations Q1342V, I1347F, and L1350Y, SUR1S2M(VFY/QIL) = SUR1S2M with mutations V1290Q, F1295I, and Y1298L. Login to comment 64 ABCC8 p.Glu1305Ala ABCC1 p.Phe1295Ile ABCC1 p.Tyr1298Leu ABCC8 p.Glu1305Ile ABCC8 p.Glu1305Gly ABCC1 p.Val1290Gln V1290Q, F1295I, and Y1298L, SUR1(QIL/III) = Q1342I, I1347I, and L1350I, SUR1(QIL/AAA) = Q1342A, I1347A, and L1350A, SUR1(QIL/GGG) = Q1342G, I1347G, and L1350G, SUR2A(EIL/III) = E1305I, I1310I, and L1313I, SUR2A(EIL/AAA) = E1305A, I1310A, and L1313A, SUR2A(EIL/GGG) = E1305G, I1310G, and L1313G. Login to comment