ABCC1 p.Cys388Gly
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PMID: 22511347
[PubMed]
Qin L et al: "Effect of multiple cysteine substitutions on the functionality of human multidrug resistance protein 1 expressed in human embryonic kidney 293 cells: identification of residues essential for function."
No.
Sentence
Comment
331
Substitution of Cys388 with seven different amino acids (C388D, C388G, C388I, C388M, C388N, C388S, and C388V) decreased the transport of LTC4 by 30% (C388V) to more than 90% (C388N).
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ABCC1 p.Cys388Gly 22511347:331:64
status: NEW332 Their effect on E217betaG transport was similar although the C388V mutation reduced transport by only 10 to 15% (data not shown).
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ABCC1 p.Cys388Gly 22511347:332:64
status: NEW