162 Recent studies on alpha-adducin e.g., demonstrated that the response to the antihypertensive agent hydrochlorothiazide is better in carriers of the gly460trp variation than in carriers of the wild-type allele (Cusi et al., 1997; Vormfelde et al., 2003).

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ABCC2 p.Gly460Trp 15554239:162:148

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176 GeneExampleClinicalconsequencesReference b2-adrenozeptorAlbuterol,isoproterenolBronchodilatationvariousincertain haplotypecombinations;tachyphylaxis, desensitisationbyagonistandeffect dependonvariant (Dishyetal.,2001; Drysdaleetal.,2000; Israeletal.,2000) Dopaminetransporter (9x40bpVNTR) L-DopaOccurrenceofpsychosisordyskinesia(Kaiseretal.,2003) 5-lipoxygenaseZileutonAsthmaticswhocarrythetandem-repeat promotervariantarenon-responders (Drazenetal.,1999) ApolipoproteinETacrinOnlyeffectiveinApoE4-negativpatients withM.Alzheimer (Poirieretal.,1995) MGMTAlkylatingagentsMethylationofpromoter,favorable therapeuticresultsinpatients withglioma (Estelleretal.,2000) KCNE2(T8AinMiRP1)Sulfamethoxazol, procainamide,oxatomide Drug-inducedlongQT-syndromein carriersofthevariant (Sestietal.,2000) GlycoproteinIIIa(PLA1 /A2 )Inhibitorsofthrombocyte aggregation (aspirin,abciximab) LesseffectiveincarriersofPLA2 (Cookeetal.,1998; Michelsonetal.,2000; Wheeleretal.,2002) CETP(B1/B2)PravastatinDevelopmentofarteriosclerosis slowerincarriersofB1B1 (Kuivenhovenetal.,1998) a-adducin(Gly460Trp)Hydrochlorothiazide(HCT)Carriersof460Gly/Tryshow betterresponsetoHCTin combinationwithsaltrestriction (Cusietal.,1997) ACE(I/D)EnalaprilatEfficacylongerandbetterincarriers ofgenotypeACE-I/I (Uedaetal.,1998) MGMT,O6 -methylguanin-DNAmethyltransferase;CETP,Cholesterolestertransferprotein;ACE,Angiotensin-convertingenzyme;VNTR,Variable numberoftandemrepeat. unsatisfactory antiemetic response.

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ABCC2 p.Gly460Trp 15554239:176:1069

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