PMID: 15554239

Roots I, Gerloff T, Meisel C, Kirchheiner J, Goldammer M, Kaiser R, Laschinski G, Brockmoller J, Cascorbi I, Kleeberg U, Hildebrandt AG
Pharmacogenetics-based new therapeutic concepts.
Drug Metab Rev. 2004 Oct;36(3-4):617-38., [PubMed]
Sentences
No. Mutations Sentence Comment
162 ABCC2 p.Gly460Trp
X
ABCC2 p.Gly460Trp 15554239:162:148
status: NEW
view ABCC2 p.Gly460Trp details
 Recent studies on alpha-adducin e.g., demonstrated that the response to the antihypertensive agent hydrochlorothiazide is better in carriers of the gly460trp variation than in carriers of the wild-type allele (Cusi et al., 1997; Vormfelde et al., 2003). Login to comment 176 ABCC2 p.Gly460Trp
X
ABCC2 p.Gly460Trp 15554239:176:1069
status: NEW
view ABCC2 p.Gly460Trp details
 GeneExampleClinicalconsequencesReference b2-adrenozeptorAlbuterol,isoproterenolBronchodilatationvariousincertain haplotypecombinations;tachyphylaxis, desensitisationbyagonistandeffect dependonvariant (Dishyetal.,2001; Drysdaleetal.,2000; Israeletal.,2000) Dopaminetransporter (9x40bpVNTR) L-DopaOccurrenceofpsychosisordyskinesia(Kaiseretal.,2003) 5-lipoxygenaseZileutonAsthmaticswhocarrythetandem-repeat promotervariantarenon-responders (Drazenetal.,1999) ApolipoproteinETacrinOnlyeffectiveinApoE4-negativpatients withM.Alzheimer (Poirieretal.,1995) MGMTAlkylatingagentsMethylationofpromoter,favorable therapeuticresultsinpatients withglioma (Estelleretal.,2000) KCNE2(T8AinMiRP1)Sulfamethoxazol, procainamide,oxatomide Drug-inducedlongQT-syndromein carriersofthevariant (Sestietal.,2000) GlycoproteinIIIa(PLA1 /A2 )Inhibitorsofthrombocyte aggregation (aspirin,abciximab) LesseffectiveincarriersofPLA2 (Cookeetal.,1998; Michelsonetal.,2000; Wheeleretal.,2002) CETP(B1/B2)PravastatinDevelopmentofarteriosclerosis slowerincarriersofB1B1 (Kuivenhovenetal.,1998) a-adducin(Gly460Trp)Hydrochlorothiazide(HCT)Carriersof460Gly/Tryshow betterresponsetoHCTin combinationwithsaltrestriction (Cusietal.,1997) ACE(I/D)EnalaprilatEfficacylongerandbetterincarriers ofgenotypeACE-I/I (Uedaetal.,1998) MGMT,O6 -methylguanin-DNAmethyltransferase;CETP,Cholesterolestertransferprotein;ACE,Angiotensin-convertingenzyme;VNTR,Variable numberoftandemrepeat. unsatisfactory antiemetic response. Login to comment