ABCB1 p.Met986Arg
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PMID: 22647192
[PubMed]
Wise JG et al: "Catalytic transitions in the human MDR1 P-glycoprotein drug binding sites."
No.
Sentence
Comment
333
A novel arginine mutagenesis approach for rescuing Pgp folding mutants was used by Loo and Clarke to argue that the bulky arginine side chain, when present in the drug binding site, mimicked the rescue of folding of certain mutations by transport substrates that has been observed.81 Alteration of known substrate affinities was taken as evidence that the A302R, F336R, L339R, G872R, F942R, Q946R, V982R, S993R, and M986R mutations were at drug binding locations.
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ABCB1 p.Met986Arg 22647192:333:416
status: NEW