ABCC2 p.Ser283Asp
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PMID: 22454528
[PubMed]
Emi Y et al: "A cis-acting five-amino-acid motif controls targeting of ABCC2 to the apical plasma membrane domain."
No.
Sentence
Comment
141
Notably, two mutants containing phosphomimetic substitutions at residue S283 , namely S283D and S283E, exhibited normal apical localization similar to that of the wild-type ABCC2 (Fig. 5).
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ABCC2 p.Ser283Asp 22454528:141:86
status: NEW159 The S283A mutant lost its apical-specific steering activity and gave the mixed staining of the lateral side in addition to the apical side, whereas the S283D phosphomimetic substitution restored apical-specific localization.
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ABCC2 p.Ser283Asp 22454528:159:152
status: NEW266 ABCC2 mutants containing phosphomimetic substitutions at S283 (S283D and S283E) showed normal apical localization, whereas mutants containing nonphosphorylatable substitutions at S283 were localized to both the apical and basolateral membranes.
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ABCC2 p.Ser283Asp 22454528:266:63
status: NEW139 Notably, two mutants containing phosphomimetic substitutions at residue S283 , namely S283D and S283E, exhibited normal apical localization similar to that of the wild-type ABCC2 (Fig. 5).
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ABCC2 p.Ser283Asp 22454528:139:86
status: NEW156 The S283A mutant lost its apical-specific steering activity and gave the mixed staining of the lateral side in addition to the apical side, whereas the S283D phosphomimetic substitution restored apical-specific localization.
X
ABCC2 p.Ser283Asp 22454528:156:152
status: NEW263 ABCC2 mutants containing phosphomimetic substitutions at S283 (S283D and S283E) showed normal apical localization, whereas mutants containing nonphosphorylatable substitutions at S283 were localized to both the apical and basolateral membranes.
X
ABCC2 p.Ser283Asp 22454528:263:63
status: NEW262 ABCC2 mutants containing phosphomimetic substitutions at S283 (S283D and S283E) showed normal apical localization, whereas mutants containing nonphosphorylatable substitutions at S283 were localized to both the apical and basolateral membranes.
X
ABCC2 p.Ser283Asp 22454528:262:63
status: NEW