ABCC2 p.Ser283Ala
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PMID: 22454528
[PubMed]
Emi Y et al: "A cis-acting five-amino-acid motif controls targeting of ABCC2 to the apical plasma membrane domain."
No.
Sentence
Comment
118
Remarkably, cells expressing the S283A/Q284A and L287A/ V288A double substitution mutants exhibited mixed staining patterns.
X
ABCC2 p.Ser283Ala 22454528:118:33
status: NEW134 In particular, two point mutants, S283A and L287A, exhibited dual localization patterns in polarized HepG2 cells.
X
ABCC2 p.Ser283Ala 22454528:134:34
status: NEW159 The S283A mutant lost its apical-specific steering activity and gave the mixed staining of the lateral side in addition to the apical side, whereas the S283D phosphomimetic substitution restored apical-specific localization.
X
ABCC2 p.Ser283Ala 22454528:159:4
status: NEW161 However, localization of S283A/Q284A and 279-283/A mutants looked mostly intracellular in MDCK cells.
X
ABCC2 p.Ser283Ala 22454528:161:25
status: NEW173 FLAG-ABCC2 (S283A) exhibited a mixed localization pattern at the basolateral membranes and the apical vacuoles.
X
ABCC2 p.Ser283Ala 22454528:173:12
status: NEW117 Remarkably, cells expressing the S283A/Q284A and L287A/ V288A double substitution mutants exhibited mixed staining patterns.
X
ABCC2 p.Ser283Ala 22454528:117:33
status: NEW132 In particular, two point mutants, S283A and L287A, exhibited dual localization patterns in polarized HepG2 cells.
X
ABCC2 p.Ser283Ala 22454528:132:34
status: NEW156 The S283A mutant lost its apical-specific steering activity and gave the mixed staining of the lateral side in addition to the apical side, whereas the S283D phosphomimetic substitution restored apical-specific localization.
X
ABCC2 p.Ser283Ala 22454528:156:4
status: NEW158 However, localization of S283A/Q284A and 279-283/A mutants looked mostly intracellular in MDCK cells.
X
ABCC2 p.Ser283Ala 22454528:158:25
status: NEW170 FLAG-ABCC2 (S283A) exhibited a mixed localization pattern at the basolateral membranes and the apical vacuoles.
X
ABCC2 p.Ser283Ala 22454528:170:12
status: NEW