ABCB6 p.Lys629Met
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PMID: 22655043
[PubMed]
Kiss K et al: "Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes."
No.
Sentence
Comment
213
DNA Constructs cDNA encoding wild-type human ABCB6 (NM_005689) bearing an HA-tag at its C-terminus [17] was mutated by mutagenic PCR to generate a variant harboring mutation of a universally conserved lysine residue in the Walker A sequence (K629M).
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ABCB6 p.Lys629Met 22655043:213:242
status: NEW215 An untagged form of both the wild-type and the non-functional mutant variant of ABCB6 (K629M, ABCB6-KM) were cloned into pSEW lentiviral vectors.
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ABCB6 p.Lys629Met 22655043:215:87
status: NEW
PMID: 25627919
[PubMed]
Kiss K et al: "Role of the N-terminal transmembrane domain in the endo-lysosomal targeting and function of the human ABCB6 protein."
No.
Sentence
Comment
41
Site-directed mutagenesis was performed to replace the conserved Walker A lysine at position 629 to methionine (K629 M), as described previously [15].
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ABCB6 p.Lys629Met 25627919:41:74
status: NEW