ABCB2 p.Lys463Ala
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PMID: 17244610
[PubMed]
Papadopoulos M et al: "Multiple residues in the transmembrane helix and connecting peptide of mouse tapasin stabilize the transporter associated with the antigen-processing TAP2 subunit."
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Sentence
Comment
39
To generate the ER retrieval signal mutant K463A/K464A of mTpn, the reverse primer 5Ј-GGCCAAGCTTATTGGGAAGCGG- CTGAGTTCCTGGGAATGGTCAGGCTGGC-3Ј was used together with the same forward primer as above and inserted into mTpn cDNA using XbaI and HindIII.
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ABCB2 p.Lys463Ala 17244610:39:43
status: NEW87 Also, the mTpn[K463A/K464A] mutant was able to substitute WT mTpn, suggesting that ER retrieval/retention is not essential for the TAP2-stabilizing function of Tpn.
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ABCB2 p.Lys463Ala 17244610:87:15
status: NEW238 Since the mutant mTpn[K462A/K463A] was fully functional in terms of TAP2 stabilization, it is conceivable that Tpn acts on TAP in the ER proper and also within the recycling pathway.
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ABCB2 p.Lys463Ala 17244610:238:28
status: NEW237 Since the mutant mTpn[K462A/K463A] was fully functional in terms of TAP2 stabilization, it is conceivable that Tpn acts on TAP in the ER proper and also within the recycling pathway.
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ABCB2 p.Lys463Ala 17244610:237:28
status: NEW