ABCA1 p.Leu222Lys
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PMID: 15017358
[PubMed]
Zannis VI et al: "Probing the pathways of chylomicron and HDL metabolism using adenovirus-mediated gene transfer."
No.
Sentence
Comment
192
Mutations M3 (apoA-I[Leu211,214,218,219Val]) and M4 (apoA-I [Leu222Lys/Phe225,229Lys]), which inhibit the binding of apoA-I to HDL and the solubilization of multilamellar DMPC vesicles in vitro, are associated with low HDL and apoA-I levels in vivo.
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ABCA1 p.Leu222Lys 15017358:192:61
status: NEW
PMID: 12488454
[PubMed]
Chroni A et al: "The central helices of ApoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux. Amino acid residues 220-231 of the wild-type ApoA-I are required for lipid efflux in vitro and high density lipoprotein formation in vivo."
No.
Sentence
Comment
309
It has also been shown that substitution of the hydrophobic amino acids L222K, F225K, and F229K of apoA-I in this region diminishes the ability of apoA-I to associate with HDL and phospholipids in vitro (43).
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ABCA1 p.Leu222Lys 12488454:309:72
status: NEW306 It has also been shown that substitution of the hydrophobic amino acids L222K, F225K, and F229K of apoA-I in this region diminishes the ability of apoA-I to associate with HDL and phospholipids in vitro (43).
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ABCA1 p.Leu222Lys 12488454:306:72
status: NEW