ABCMdb

PMID: 12488454

Chroni A, Liu T, Gorshkova I, Kan HY, Uehara Y, Von Eckardstein A, Zannis VI
The central helices of ApoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux. Amino acid residues 220-231 of the wild-type ApoA-I are required for lipid efflux in vitro and high density lipoprotein formation in vivo.
J Biol Chem. 2003 Feb 28;278(9):6719-30. Epub 2002 Dec 17., [PubMed]

Sentences

No. Mutations Sentence Comment

306 ABCA1 p.Leu222Lys It has also been shown that substitution of the hydrophobic amino acids L222K, F225K, and F229K of apoA-I in this region diminishes the ability of apoA-I to associate with HDL and phospholipids in vitro (43). Login to comment 309 ABCA1 p.Leu222Lys It has also been shown that substitution of the hydrophobic amino acids L222K, F225K, and F229K of apoA-I in this region diminishes the ability of apoA-I to associate with HDL and phospholipids in vitro (43). Login to comment