ABCD1 p.Lys435Met
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81
(53) As the excretion of phospholipids and cholesterol was not observed with MDR2- K435M or MDR2-K1075M, in which the Walker A lysine in either NBF was substituted by methionine, MDR2 mediates lipid efflux in an ATP-dependent manner, like other ABC transporters; however, no lipid secretion was observed from HEK293 cells expressing MDR1, even in the presence of bile salts.
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ABCD1 p.Lys435Met 17608770:81:83
status: NEW